OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222.
What are antihemophilic drugs?
These agents are used to control bleeding in hemophilia B or FIX deficiency and to prevent and/or control bleeding in patients with hemophilia A and inhibitors to FVIII. These are used to control bleeding in mild hemophilia and in some forms of von Willebrand disease.
Which drug has a recombinant antihemophilic factor?
QUESTION. The use of RECOMBINATE (antihemophilic factor (recombinant)) rAHF is indicated in hemophilia A (classical hemophilia) for the prevention and control of hemorrhagic episodes.
Which factor is known as Antihemophilic?
Factor VIII (antihemophilic factor) is the protein that is deficient or defective in patients with classical hemophilia and Von Willebrand syndrome.
What is Factor 9 in the blood?
Factor IX is a protein that helps your blood clot. If you are lacking this protein, you may have a bleeding disorder called hemophilia B. Hemophilia B is found mostly in males. When people with hemophilia get cut or injured, bleeding is hard to stop because their blood does not have normal clotting substances.
What is another name for antihemophilic factor?
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade.
Which is known as Christmas factor?
The clotting factor IX is also known as Christmas factor. The name is derived from the boy, Stephen Christmas. He was lacking this factor and the deficiency led him to acquire hemophilia. The Christmas factor is produced from the liver.
What is antihemophilic factor used for?
Human antihemophilic factor is used to treat or prevent bleeding episodes in people with hemophilia A. It is also used to control bleeding related to surgery or dentistry in a person with hemophilia.
What is Factor 8 called?
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the F8 gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder.
How much does factor 9 cost?
See above for information about the drug. The per patient cost for this drug was $366,496 in 2014. This Coagulation Factor IX drug is used to control and prevent bleeding in patients with hemophilia B. The cost per patient in 2014 was $302,364.
How do you factor 8?
Factor VIII is generally administered as a slow IV push (bolus injection). Continuous infusion of Factor VIII is indicated for patients requiring admission for severe bleeds or surgical procedures. Factor VIII replacement for such patients should be managed in consultation with Clinical Haematology.
What is stable factor?
Definitions of stable factor. a coagulation factor formed in the kidney under the influence of vitamin K. synonyms: cothromboplastin, factor VII, proconvertin. type of: clotting factor, coagulation factor. any of the factors in the blood whose actions are essential for blood coagulation.
What is blood clotting factor?
Coagulation factors are proteins in the blood that help control bleeding. You have several different coagulation factors in your blood. When you get a cut or other injury that causes bleeding, your coagulation factors work together to form a blood clot. The clot stops you from losing too much blood.
What is a factor IX test for?
This test is used to find the cause of too much bleeding (decreased blood clotting). Or, it may be ordered if a family member is known to have hemophilia B .
What is factor 10 called?
COAGULATION CASCADE | Factor X
Factor X (fX), also called Stuart factor, is a vitamin-K dependent serine protease zymogen that is activated in the first common step of the intrinsic and extrinsic pathways of blood coagulation.
What is Factor 9 called?
Factor IX (or Christmas factor) (EC 3.4. 21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes haemophilia B.
Why is hemophilia B Christmas?
Hemophilia B occurs when clotting factor IX is either absent or not present in sufficient amounts. Hemophilia B is also known as Christmas disease. It is named after the first person to be diagnosed with the disorder in 1952, Stephen Christmas.
What is factor 7 called?
Factor VII (EC 3.4. 21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class.
What Is factor VIII?
Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder.
Is Factor 8 an injection?
Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII. Certain preparations may also be used in those with von Willebrand’s disease. It is given by slow injection into a vein.
How is Factor 9 activated?
Coagulation factor IX is made in the liver. This protein circulates in the bloodstream in an inactive form until an injury that damages blood vessels occurs. In response to injury, coagulation factor IX is activated by another coagulation factor called factor XIa.
What is a normal factor 9 level?
Normal plasma levels of factor IX are 50 to 150 units/dl. Patients with levels less than 1 unit/dl have severe disease, those with levels of 1 to 5 units/dl moderate disease, and those with levels greater than 5 units/dl mild disease. The half-life of factor IX is approximately 18 to 24 hours.
Why is Factor 9 called Christmas factor?
It is also known as factor IX deficiency, or Christmas disease. It was originally named “Christmas disease” after the first person diagnosed with the disorder back in 1952. Hemophilia A is 7 times more common than hemophilia B, occurring in about 1 in 25,000 male births in US and 1 in 30,000–60,000 in India.