It is an important area since absorption of drug depends largely on physiochemical considerations. … this is most important to know about the physicochemical properties, this predict and effect the flux, bioavailability, of drug in TDDS, or TDDS microemulsion.
What is physicochemical properties in medicinal chemistry?
PHYSICo chemicaL PROPERTIES. DEFINITION: The ability of a chemical compound to elicit a pharmacological/ therapeutic effect is related to the influence of various physical and chemical (physicochemical) properties of the chemical substance on the bio molecule that it interacts with.
What are physicochemical properties?
Physico-chemical properties are the intrinsic physical and chemical characteristics of a substance. These include appearance, boiling point, density, volatility, water solubility and flammability etc.
What are the example of physicochemical properties?
For example, the IC2 framework lists a variety of physicochemical properties that should be considered when assessing exposure pathways, including: volatility/vapor pressure, molecular weight and size, solubility, logP (as Kow), boiling point, melting point, density/specific gravity, pH, corrosivity, and dissociation …
What is physicochemical properties of soil?
Physical chemical properties of the soil, such as bulk density, porosity, pH, and soil organic carbon, summarized in Table 2, are usually considered as indicators of soil quality35,36. The three soils are slightly alkaline, with pH from 7.83 to 7.94.
Which one of these is a physicochemical property of drug substance?
Explanation: Physicochemical properties of drug substances include drug solubility, dissolution rate, particle size, effective surface area, polymorphism, etc. Dissolution time comes under Dosage form characteristics and pharmaceutic ingredients.
What are physicochemical tests?
Physicochemical (or physchem) testing is an integral requirement of product registration for agrochemicals, biocides, chemicals, and animal health products. … We have also worked with a wide variety of industrial chemicals, including dyes, flavor and fragrance substances, monomers, fluorinated chemicals, and inorganics.
What are the properties of medicines?
Drug-like properties, such as solubility, permeability, metabolic stability and transporter effects are of critical importance for the success of drug candidates. They affect oral bioavailability, metabolism, clearance, toxicity, as well as in vitro pharmacology.
What is physicochemical properties that affect bioavailability?
The physicochemical properties of the drug that will influence its passage into solution and transfer across membranes include its dissolution rate, pKa, lipid solubility, chemical stability and complexation potential.
What are the objectives for study of physicochemical characterization of drug substance?
The objectives of preformulation studies are to choose the correct form of your drug substance, evaluate its physical properties and generate a thorough understanding of the material’s stability under various conditions, leading to the optimal drug delivery system.
What the body does to drug?
Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption.
What is physicochemical process?
Physicochemical processes are the normal intracellular and extracellular physical and chemical processes that are crucial for maintenance of normal homeostasis of a cell. These reactions are vital for the wellbeing of the cell and provide essential energy for its survival.
What are some examples of properties?
Familiar examples of physical properties include density, color, hardness, melting and boiling points, and electrical conductivity. We can observe some physical properties, such as density and color, without changing the physical state of the matter observed.
What is the difference between physiochemical and physicochemical?
As adjectives the difference between physicochemical and physiochemical. is that physicochemical is dependent on the joint action of both physical and chemical processes while physiochemical is of or pertaining to both physiology and chemistry.
What are the physicochemical properties of nanoparticles?
Physicochemical characteristics of nanoparticles and engineered nanomaterials including size, shape, chemical composition, physiochemical stability, crystal structure, surface area, surface energy, and surface roughness generally influence the toxic manifestations of these nanomaterials.
Which one of these is not a theory of drug dissolution?
Which one of these is not a theory of Drug dissolution? Explanation: Fick’s law of diffusion states that drug molecules diffuse from higher concentration to lower concentration until equilibrium is reached.
Which kind of drugs are absorbed through endocytosis?
Which kind of drugs are absorbed through endocytosis? Explanation: Macromolecular drugs, Drugs as solid particles and drugs as oily particles are absorbed through endocytosis.
How do physical properties of drugs?
Physicochemical properties underlie all aspects of drug action and are critical for solubility, permeability and successful formulation. Specific physicochemical properties shown to be relevant to oral drugs are size, lipophilicity, ionisation, hydrogen bonding, polarity, aromaticity and shape.
What are the 5 properties of soil?
All soils contain mineral particles, organic matter, water and air. The combinations of these determine the soil’s properties – its texture, structure, porosity, chemistry and colour.
What are the three main physical properties of soil?
The particles that make up soil are categorized into three groups by size – sand, silt, and clay. Sand particles are the largest and clay particles the smallest. Most soils are a combination of the three. The relative percentages of sand, silt, and clay are what give soil its texture.
What are the soil physical properties?
Physical properties of soil include color, texture, structure, porosity, density, consistence, aggregate stability, and temperature. These properties affect processes such as infiltration, erosion, nutrient cycling, and biologic activity.