How Extended Adderall Use Affects the Brain. Stimulants increase concentration and energy levels while decreasing the need for sleep and suppressing the appetite. Adderall increases the activity of several neurotransmitters, such as serotonin, norepinephrine, and especially dopamine.
How do amphetamines affect norepinephrine?
Both amphetamine and cocaine increase norepinephrine (NE) via stimulation of release and inhibition of reuptake, respectively.