Does Atropine Increase Heart Rate And Blood Pressure?


COMMON side effects

  • visual sensitivity to light.
  • blurred vision.
  • dry eye.
  • dry mouth.
  • constipation.
  • decreased sweating.
  • reactions at the site of the injection.
  • intense abdominal pain.

Is atropine contraindicated in hypertension?

Use with caution in patients with coronary heart disease, acute myocardial ischemia, congestive heart failure, tachycardia, or hypertension as the increased cardiac demand and possible further worsening of tachycardia and hypertension can prove detrimental to patient outcomes.

What does atropine do to the heart?

Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.

What does atropine do to blood pressure?

Atropine in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.

What is atropine used to treat?

Atropine is a prescription medicine used to treat the symptoms of low heart rate (bradycardia), reduce salivation and bronchial secretions before surgery or as an antidote for overdose of cholinergic drugs or mushroom poisoning. Atropine may be used alone or with other medications.

Why is atropine given?

Atropine is used to help reduce saliva, mucus, or other secretions in your airway during a surgery. Atropine is also used to treat spasms in the stomach, intestines, bladder, or other organs. Atropine is sometimes used as an antidote to treat certain types of poisoning.

Who should not use atropine?

myasthenia gravis, a skeletal muscle disorder. closed angle glaucoma. high blood pressure. coronary artery disease.

Does atropine cause tachycardia?

Any central muscarinic effects of high-dose atropine on RR interval are masked by peripheral muscarinic blockade at the sinoatrial node, which causes tachycardia.

What happens if you give too much atropine?

Excess doses of atropine sulfate may cause side effects such as palpitations, dilated pupils, difficulty swallowing, hot dry skin, thirst, dizziness, restlessness, tremor, fatigue, and problems with coordination.

Is atropine a steroid?

No, atropine (Isopto Atropine) is not a steroid eye drop. Instead, atropine (Isopto Atropine) belongs to a class of medications called anticholinergics, and it works by blocking certain (muscarinic) receptors in the eye.

What drugs interact with atropine?

Most frequently checked interactions

  • Acetylsalicylic Acid (aspirin)
  • Activated Charcoal (charcoal)
  • Adrenalin (epinephrine)
  • Ativan (lorazepam)
  • Atrovent (ipratropium)
  • Benadryl (diphenhydramine)
  • Cardizem (diltiazem)
  • Dextrose (glucose)

What conditions will atropine not increase heart rate?

Atropine has little effect on systemic vascular resistance, myocardial perfusion pressure, or contractility. Atropine is indicated for the treatment of bradycardia associated with hypotension, second- and third-degree heart block, and slow idioventricular rhythms. Atropine is no longer recommended for asystole or PEA.


How much does atropine increase heart rate?

We studied the effect of atropine on heart rate in explanted perfused mouse hearts (ex vivo Langendorff preparation) which lack any nervous innervation. As expected, a low dose of ISO increased the basal heart rate by ~10%.

How does atropine affect the brain?

Atropine is primarily effective in treating the muscarinic effects of OP poisoning, especially in its effects on bronchial secretions, It has no effect on the neuromuscular junctions. Atropine crosses the blood-brain barrier and counters the effects of excess ACh on the extrapyramidal system.

What is the treatment of atropine toxicity?

Early treatment of atropine overdose can be life-saving. Stabilisation of cardiac circulation and neurology should be attempted in prehospital care. Patients with central nervous system findings or with respiratory insufficiency should be intubated.

How long does atropine stay in your system?

How long do the effects of the atropine last? The blurred vision, caused by the atropine, will last for approximately seven days after the last instillation. The dilated pupil may remain for as long as 14 days.

Is atropine a poison?

In overdoses, atropine is poisonous. Atropine is sometimes added to potentially addictive drugs, particularly antidiarrhea opioid drugs such as diphenoxylate or difenoxin, wherein the secretion-reducing effects of the atropine can also aid the antidiarrhea effects.

What is atropine used for in emergency situations?

It is used in emergency situations when the heart beats too slowly, as an antidote to for example organophosphate insecticide or nerve gas poisoning and in mushroom poisoning. It can be used as part of the premedication before general anaesthesia.

What is another name for atropine?

BRAND NAME(S): Isopto Atropine. USES: This medication is used before eye examinations (e.g., refraction) and to treat certain eye conditions (e.g., uveitis). It belongs to a class of drugs known as anticholinergics. Atropine works by widening (dilating) the pupil of the eye.

What happens when you inject atropine?

Atropine Injection is given before anaesthesia to decrease mucus secretions, such as saliva. During anaesthesia and surgery, atropine is used to help keep the heart beat normal. Atropine sulfate monohydrate is also used to block or reverse the adverse effects caused by some medicines and certain type of pesticides.

How is atropine given?

Atropine is administered by intravenous injection or intramuscular injection. Other pharmaceutical forms/strengths may be more appropriate in the cases where a dose above 0.5 mg is required. All these contra-indications are however not relevant in life-threatening emergencies (such as bradyarrhythmia, poisoning).

What is the antidote for atropine?

Physostigmine, given as an atropine antidote by slow intravenous injection of 1 to 4 mg (0.5 to 1 mg in pediatric populations), rapidly abolishes delirium and coma caused by large doses of atropine.

When should you give atropine?

Atropine is useful for treating symptomatic sinus bradycardia and may be beneficial for any type of AV block at the nodal level. The recommended atropine dose for bradycardia is 0.5 mg IV every 3 to 5 minutes to a maximum total dose of 3 mg.